Good news.
Statically, I’ll probably need this type of therapy within the next 10-15 years. I hope it’s ready for general clinical use by then.
This is just epic news. Well done all the scientists for making this happen. :)
I want this so bad, I have lost all cartilage in my wrists and I don’t want to get them fused.
I couldn’t imagine how shitty that must be, I really hope this advancement does help you regrow yours so you don’t have to get them fused.
I would like to order one new left knee cartilage please!
Just take some from someone. Jeez, the learned helplessness of some people…
People have TWO for gosh sakes…horders now days…
A person only has one cartilage once you get rid of all the useless junk like a skeleton and heart and brain.
i have femoral head necrosis, though so technically not arthritis but that is absolutely great news for everything else
…but does it cause cancer.
“but does it cause cancer” is the new “but so does a handgun” comic.
Call me dumb, but I actually don’t understand what the takeaway is.
The implication is that the cancer cure would kill you the same as a hangun would.
Ah, gotcha. Also, I fixed that horrendous typo lol; kudos for inferring it!
Cheers!
Man, I thought the opposite, you’re does make sense. I thought they were trying to say the claims were meaningless, since you obviously can’t shoot the infection/cancer.
I would trade cancer down the road for my joints working now :(
Genuinely one of the questions that is coming up more and more in healthcare is trying to figure out what cancer is okay to just live with. As in, the treatment would be more of an impact on quality of life vs letting the cancer develop slower than the person would die of other causes.
This is especially becoming more of an issue as we get much better at detecting cancer.
That’s a Future You problem. You want this or not?
Probably worth adding “in mice” to the title
Mice are really living in a golden age. They have never been so healthy.
Well they did pay for it.
The only downside is the never ending genocide at the hands of scientists
Is it still genocide if the ones killing are also reproducing them?
It’s kinda worse. Imagine if aliens came here and not just killed us all, but bred us only to be experimented on and then horribly dying with less than 1% living a bit longer and maybe experience some odd things the others didn’t. Like a factory where the first machine is making us have children before we get killed then doing the same for our kids ad infinitum.5
The mice need a floatilla and a few celebrities to turn on the red carpet and go “Yeah but what about the genocide of mice? – Chekmate, deuces.”
Did they test sildenafil on mice
And simultaneously unhealthy (otherwise how are we"curing" them)
Uhhh you do know what happens to them at the end of the experiment right?
They turn into a soup-like homogenate. As is natural in the life cycle of a lab mouse.
And if they weren’t euthanized they would almost certainly die of horrible horrible cancerous tumors. Not because of anything the labs do, but because it’s a crime against nature for a mouse to live past maybe 2 years.
Now we only need a drug to turn humans into mice and back.
Cindarellazine.
And human tissues, and it’s been shown to be safe in phase I trials.
So saying “in mice” undersells where they are at.
The language I see is regeneration in mice, less breakdown in humans
Yeah looks like poster either didn’t read the article or just didn’t read it sufficiently but decided to be reactionary anyways.
This is not the xkcd I thought you were going to use
Which one did you have in mind?
So “xkcd” is now a genericised noun for any comic? Also, is this xerox a Canon?
“four letter science comic”
Are you really that offended I linked to a relevant comic that wasn’t xkcd?
Protip, being abrasive makes people not want to talk to you.
I take it you didn’t read the conversation to get the markers about the topic before posting that.
Lots of reading comprehension problems in these science posts
They started with mice. As does all experiments.
Did you only read half way through before reaction posting?
Weird.
it’s weird to comment “weird” on everything
Yes it would be. Good thing that’s not happening. How’s the spread of the misinformation? I see I’m hitting a few nerves.
GOOD.
I’m glad to hear that stuff like this is still going on. Nice!
in fact, we’re in the early days of human gene technology, hormone therapy, biochemistry tempering etc.
🦀🦀🦀🦀🦀🦀🎉🎉🎉🎉🎊🎊🎊🎉🎊🎊
Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it’s time we start getting serious about anti-aging and life extension.
But probably not, seeing what the world is like.
Well I would argue beta decay is an aging-like property inherent in atoms. Granted, the half-lives are pretty long, but a limit still technically exists in that respect.
Its mostly billionaires who will be able to benefit from life extension… do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?
Luckily there’s no vaccine against guillotines.
Give it time.
Aroooooo
So essentially Altered Carbon?
I think that’s more kinda digitised, transferable consciousness. I’d take it tho.
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Billionaires, and everybody living outside the US
Why do you think that? We already benefit from life extension. And why only 300?
“I plan to live forever, of course, but barring that I’d settle for a couple thousand years. Even five hundred would be pretty nice.”
CEO Nwabudike Morgan, “Sid Meier’s Alpha Centauri” (1999)
That was the Civ game I got into the most! Nice callback.
Still available, on GOG Games at least.
No worries about that, there is no changing the maximum age seemingly, not unless you genetically engineered babies with tech we don’t have yet.
Everyone is born with stem cells that carry so many copies of cells that are preprogrammed to die after a point to then be replaced by those stem cells. No drug can make more copies after the fact.
Then of course the dna gets denatured just by radiation and pollution and time.
Neither of these will or can be solved after someone is born. They can extend the average lifespan of a group, but they can’t exceed the maximum, which has remained constant throughout human history even as the average has changed drastically.
All of those things seem to be related to information processing, not any inherent property of atoms.
“Then of course the dna gets denatured just by radiation and pollution and time.”
Pretty sure “dna” isn’t just present in one cell in the body.
Also, how can two thirty year olds make a zero year old baby?
Have you read anything about this before espousing your grand pronouncements here?
Seriously, like, you are so far in left field here, I can’t even respond.
https://vadim.oversigma.com/MAS862/Project.html
But lay on MacDuff, pour your great knowledge upon me. Tell me how a carbon atom knows it’s in a thirty year old body or 95 year old?
“Also, how can two thirty year olds make a zero year old baby?”
Surely you can respond to this puzzler? Even if I’m in the left field of the Andromeda Galaxy?
Explain away, professor!
If you want to address the scientific points I made, I will respond. Your poetry is neither here nor there, pal.
What’s the maximum? About 120?
Imagine having 100 or more healthy years. That seems like sci-fi, but may be possible one day still.
It will also mean working until you’re 100 before the national pension kicks in unfortunately lol
Around 120 is maximum yes. I think some french woman might have gotten near 130 but I forget.
Unless you believe the bible, in which case hundreds and hundreds of years. And woman was made from man’s rib. Makes sense.
National pension
Ngl, you had me in the first half…
They nearly had me in the first quarter, but now I no longer believe I’ll ever see it. Not enough young people are born. My generation is enough to support the current old people, but there won’t be enough people to support my generation.
Are there enough people at the current system where the top 1% get 99% of the resources? ¯\_(ツ)_/¯
But there will 100% be enough people to keep the basics going
We are thousands of times more efficient than we were a couple hundred years ago.
If you’re that worried, start working towards killing them. Seems like it’s going to be necessary step either way to correct many problems in the world. What’s one more reason for the pyre?
Only the rich will benefit.
… for the first 20 years
… and everybody else outside the US
I didn’t realize people weren’t being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.
LOL that pays for a focus group for branding. You can’t be serious.
You’re telling me you’re a “huge nerd,” but think medical research is done by companies and involves focus groups? Like, it’s a Marvel or something?
Jfc. If 90 million dollars isn’t anything to you, howbout you give yours away then bud.
Yes, medicine is marketed. Are you for real? Like, is there still amniotic fluid behind your ears? Great Hatching Day fellow creature! Welcome to Earth!
My joke was that tens of millions of dollars to research aging barely covers the test tubes. JFC.
Bud, they don’t market for a treatment before there’s even research conducted. How the fuck are you acting like you think giant research grants are not effort? Give me ten million dollars if it isn’t much then.
Sigh. What kind of absurd logic are you using? Do you not get sarcasm? I’m saying in the scheme of things, ten million dollars is nothing. The fact I don’t have ten millions dollars is irrelevant and your type of argument is at the level of an eight year old’s.
We spend more than that developing idiotic video games that mean nothing.
“Le Sigh. You are but a juvenile child, and I the calm and logical adult. The arguments I make are simply too complex for such an underdeveloped mind; my explanations would only fall on deaf ears. Even the machinations of my coy wordplay is lost on you, clearly, for you could not even decipher the hidden meaning behind my deceptively foolish appraisal of this society’s motivations. My account is of the sheer scale of human productivity, a folley by which your feeble little brain could not even begin to comprehend.”
Dude, you’re cringe. People have literally been obsessed with medicalizing anti-aging since before the Renaissance. You think we’re only just now, in 2026, taking arthritis seriously? C’mon. You said something dumb and you’re too much of an internet trilby enthusiast to even take a second and consider what it means that thousands of people are applying for, acquiring, and expending massive amounts of grant funding toward this endeavour and have been doing so for decades.
Not gonna be engaging with this anymore, only made this comment because of how you characterized yourself in this response.
How about not life extension but quality of life extension instead (e.g. this post)
Indeed, I don’t really feel like living for more more than 90 years, I just want to be able to do what I like to do until I die.
People have been seeking life extension for all of recorded history.
And we’ve achieved some of it, or are you telling me giving birth in hospitals, vaccines, and working in air conditioned offices doesn’t extend life somewhat? People were also seeking powered flight for all of recorded history.
Most people are referring to the inherent genetic features of our biology that causes aging. Because we didn’t even know such a features existed until relatively recently. Before that was discovered we thought aging was just caused by all the crap life throws as us and it looked like all we had to do was just keep improving things to functionally have humans who live "forever. "So as far what I’ve heard from scientists, we’re at wall in this area because we still have no idea what the vast majority of the genome even does.
Is it though? The only time progress happens is when people die.
Why is progress your target? Progress happens when ideas die.
Bcz people resist change, even scientists.
This and then the new about regrowing teeth. Its a very exciting time in medicine.
If you think anyone but the elite will be able to afford or procure these procedures, you’re incredibly optimistic.
As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.
So… anywhere but the USA it will be affordable(ie free) anyways? Okay.
Bremonia will have the procedures, for free. The name can be changed, I don’t care. I just need help overthrowing a few corrupt governments and I’m out.
“Everything sucks.”
Boring.
This drug can be delivered via pill. It has a range of effects in reversing age related damage.
I’m not sure if it will be kept to the rich, or given out widely to justify the removal of social security, or at least jacking up the retirement age.
Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose…
They openly want to reduce the population in the US by over 100 million. It will absolutely be kept to the right kinds of people, which are the wrong kinds of people.
If the worker-slaves live longer, you don’t have to indoctrinate & capture new ones quite as often!
I’d like my partners knees to work again so they can do the things they like as they age, like riding bikes or hiking.
I’d like my partner’s knees to work again so they can do something I like. On their knees. To me.
There’s also some riding somewhere in there I suppose.
Lol Yankee problems
I’m not a Yankee, but thanks for assuming
You’re an American, that’s what Yankee means to everybody outside the states.
I’m old school American
#landback!!!
Are you seriously also down here saying racist shit to a Native American so that you can roleplay some flex on what you thought was just some poor USAmerican who couldn’t afford healthcare? Your good guy scenario was dunking on a poor person in an authoritarian state?
Europeans are seriously the most bloodthirsty fucks I’ll see online, and they’re predictably the most smug about it too.
I have no idea what you’re trying to say. Are you saying he’s NOT an American because he’s indigenous? And wtf is racist? At least now I know what his comment means. You people think everybody knows the same things you do.
(I’m Asian BTW, but yeah go on)
Oh but how dare you be Asian when you were already assigned European at post /s
“It isn’t racist to call a Native American a ‘yank’ because I’m ignorant about racism.” You’re telling me that you moderate a Norwegian community, talk a shit ton about Euro nations, but you think it doesn’t make you look like a racist asshole to not know what is racist about trying to dunk on an indigenous person (who, again, you thought was just some other poor person) by calling them a term that identifies them with the occupying settler state that has committed genocide against their people.
Yeah dude, totally not a bloodthirsty chud.
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Ready for someone to tell me why this unfortunately won’t work / become mainstream
Money, usually. Or cancer. God i sound depressing 😄
Money cancer.
Ah, the billionaires again.
Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.
Because PDGH-15 also causes age related muscle weakness.
Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.
I don’t know if the results of the phase 1 trials have been published yet, but it’s been a while since I checked.
I’ve been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.
Wow, this is really exciting. I guess it’ll take years more research before we’ll know if this can benefit humans, but if they can replicate the results with humans then it could potentially prevent chronic pain and mobility issues in millions of people.
Hopefully not just humans. Many dogs for example suffer from the very same issues when they get older.
it’s always seemed weird to me that aging takes 20 years in dogs but 80 years in humans. i mean, if it’s a physical hardware failure, then you would expect it to be independent of age and only dependent on past physical load.
Not a scientist, but from what I know it’s all linked and proportional to a species’ lifespan, so dogs are growing up faster, but also aging faster than humans in general. If a human reaches sexual maturity at 15, a dog does so at 1 or 2.
Take a drug to regrow cartilage and get w vaccine for the cancer it allows.
With enough science, anything is possible.
I wonder if that’ll be the route to immortality from age.
The drug that stops the aging, and a drug that stops the cancer.
Trying to solve just the aging never works, but the combo does.
Or it causes some new, unexpected side effect
Super human powers when you start growing extra ears or eyes?
I was imagining something that kills you or makes you wish you were dead. But hey, Xmen powers would be cool too.
… potentially prevent chronic pain and mobility issues in
millions oftens of ultrarich people.FTFY
Americans, we get it, you have no healthcare system worth the name. Stop assuming nobody else worldwide can get the meds either.
Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.
The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn’t matter how much it costs.
Or maybe you could show a little sympathy once in a while
You try running into comments thinking they’re the only nation on earth in every health article and see how long you stay sympathetic.
America did this shit to itself
And the civilised world gets dragged into the bullshit
And before you whine, the majority of Americans are a part of the problem in one way or another
Your society (for want of a better term) has gotten what it collectively wants
Sorry, is this not meant to sound like you’re a Eurocentrist douchebag? Medical care and resources are already not distributed proportionately throughout the world exactly because a small number of nations benefit from a brutally extractive colonial system that requires the dehumanization of other groups to exist.
The US doesn’t have a fucking healthcare system because it is a settler-colonial, imperialist military power that holds up the capitalist system that Europeans are such proud benefactors of. They violently enforce a system that inflicts as much precarity and vulnerability as possible on its people because it depends on preventing as many unprivileged people as possible from gaining enough resources to muster an effective challenge to its power within the metropole while maintaining its legitimacy to its more privileged working classes.
So, what the fuck are you bitching about? Americans saying that people won’t be able to afford it? They’re correct, most people will not have access to it so that fucks like you can thanks to the US guarding the loot. Fuck’s sake with you people.
Edit: Before any Euros try to bitch and whine about how unfair it is that you’re still colonizers, I do not care. I don’t fucking care. We are not going to do this thing where you can bitch about the US and pretend like you aren’t world destroyers for the same exact fucking reason it is. If you are not critical of how many EU and European settler nations have the wealth to sustain a healthcare system and quality of life that makes access to medicine an entitlement instead of a privilege, you’re not a serious person.
I’m Asian. My country was colonised by Europeans till half a century ago.
Keep going, this is funny. We’ve gone from ‘America is the only nation on earth’ to ‘oh yeah, Europe exists too’.
I’m Eastern European, my country was exploited by USSR until less than 40 years ago. My bad for getting excited about the prospect of being able to walk in old age, it’s all my fault for -checks notes- joining a freedom of trade and movement organisation
You imperialist coloniser superpower douchebag!
my country was exploited by USSR
Do you have a source for that? The inefficiencies of Communism and the lack of cheap third world resources is not the same as being colonised or post-colonised like a third world country.
I’m not entering the exploitation olympics here, feel free to disregard my argument if Eastern Europe doesn’t clear the suffering threshold in your book.
Not necessarily what you’re looking for, but provides some interesting context for others
Why not? It shows that the USSR was doing the opposite.
However, especially by the end, the USSR was effectively paying to keep satellites afloat.
The first comment mentions as exploitation the dismantled production lines from East Germany. Counting war reparations as exploitation is not a honest argument.
The author shifts the tone latet-on.
It doesn’t necessarily mean it was a benefit for the satellites either, though. There’s a case to be made it was mutually detrimental to both parties.
Maybe orioler25 will figure out that there’s more to the world than only the US and EU :D
Doubtful
Reread the comment and tell yourself that a criticism of EuroAmerican global imperialism is without consideration of colonized peoples. This history happened, sorry it compromises whatever power fantasy you have.
Reread the comment.
Waaah they called out my US defaultist ass and now I need to crash out that the Euros built functioning societies waaaaaaaah
Hey, how’d they build those “functioning” societies? Got a source? Extra points if you can even cite a decolonial history written by an indigenous person.
Nice little extra ableism in your comment too, like a good colonizer chud would say.
Reeeee anything I don’t like is brutal colonialism! Those damn Irish colonising Ireland! Don’t get me started on the fucking Icelanders! Reeeeeee
You’re saying you think it makes you sound smart to suspend your object permanence. Guess a capitalist system with so much wealth concentrated in the EU just happened, it’s just like that. If you want to be in the Colonial League of Doom, every single individual in your country must personally be a rubber baron. Otherwise, you’re valour stealing bastards, actually free from colonialism completely, and a hysterical blue haired SJW.
I seriously don’t know how you could type this shit and still respect yourself.
The Irish are famously perpetrators and beneficiaries of colonialism
Australian here
Fuck off with your whining
You idiots did this to yourselves, ironically as a collective, because of your worship of the individual over society
Suck it, yank.
Says the guy that just let the trojan horse of age controls behind the walls of their liberal democracy. Get off your high horse mate, it’s time for your colonoscopy to prove you can use the internet so they can craft your social score off of all your information on half baked palantir ai models. Oi oi oi!
Not USAmerican. I’m willing to bet your colonizing ass doesn’t even know about Australia, look up Patrick Wolfe.
When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]
Sounds very promising! I couldn’t figure out the peer-reviewed-ness status.
Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).
I think I’d be okay with some stomach irritation to regain use of my knees in my old age.
in mice though, since none of these recent one works in humans yet.
