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“I had one, but I wasn’t feeling it so I took more…” is the start to almost every bad trip story lol
Isn’t Benadryl linked to early onset dementia
Edit:
Maybe not early onset, but it is statistically linked to dementia risk and that’s enough for me.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2736353
https://en.wikipedia.org/wiki/Diphenhydramine#Adverse_effects
thats the purpose of antihistamines to slow you down so the histamine response is also lessened enough that your body will get over it sooner
4 Benadryl is also known as “teleportation spell, level 1.” Because you will doze off and then a few hours later wake up somewhere else, with no recollection of how you got there.
I’ve tested this accidentally once. It works. I took two, fell asleep for a few mins, woke up and having forgotten I’d already taken some, took two more. I woke up at 11pm on a Sunday night inside the closed & empty cafeteria of the local community college, with no car.
That’s more kpins. Will never forget the friend who set a house on fire and then didn’t remember she did until she remembered she left her purse in there. A close friend was fucked up on them one time and showed up at my house and was blacking out every 8 mins and then left my house and I was fucking worried about him the whole day and then he’s like nahhhh man I had a great time yesterday and I’m like what the fuck.
The wild variations in what people consider “a great time” will never cease to amaze me.
That is fucking scary.
Growing up with severe allergies to pretty much anything with 4 legs, and the self control of a toddler who just spotted a cute-ass puppy… yeah I went through a lot of benadryl. What I’ve learned after a lifetime of eating that shit like candy: you gain a tolerance to it like any other drug.
My super power now is I can eat a whole handful of that shit and it’ll do nothing. No drowsiness. No hatman (is that actually a thing, or is this just some weird internet bullshit?). The tradeoff being: no relief from allergies. Which is kind of a bummer considering allergies can do things like close your airway.
Morale of the story: ROTATE YOUR ANTIHISTAMINES!! If you’re taking that shit every day, use benadryl one day, then loratadine the next, then cetirizine the next, etc. Give your body breaks from any one of them so you have time to shake that tolerance before it develops. Cuz when you need it to work, you NEED it to work!!
Bonus tip: read the back labels of your meds. You’d be amazed how much shit is just rebranded and price-jacked diphenhydramine (benadryl). Especially sleep aids… like that “Zzzquil” shit is just stupid expensive benadryl.
Bonus tip tradeoff: you just lost any benefit you might have been gaining from the placebo effect. Sorry.
i read this article that some placebos work even if you know they’re placebos. i’m not awake enough to find it right now tho
That I didn’t know, but they absolutely work if you don’t know it’s a placebo!
So… don’t go correcting Grandma when she starts talking about how healing crystals and acupuncture cured her arthritis. “I’m so glad you found a solution!!” and start talking about cookies or some shit.
Bonus tip: read the back labels of your meds. You’d be amazed how much shit is just rebranded and price-jacked diphenhydramine (benadryl). Especially sleep aids… like that “Zzzquil” shit is just stupid expensive benadryl.
There are like four or five different active ingredients in the entire pharmacy. Find whatever you want, check the active ingredients, then just find the cheapest with the same name and number.
On that note, Costco!
Fr fr. If you suffer from allergies and take one of the OTCs it’ll pay for the card over a year.
Does rotating them actually work? I thought they all just blocked your histamine receptors, so your body couldn’t care less just which substance did that for expressing more histamine receptors / making more histamine, thereby developing tolerance.
Edit: Yeah, so I hate to place a nocebo here, but taking a break, not rotating them, seems to be the only effective remedy to anti-histamine tolerance. That is, if taking a break is tolerable, of course. I don’t know if that has to be said but please take medical advice from your health care professional of choice and not from a lemmy comment.
Tolerance developed to one antihistamine extended to others, even though the chemical relationship was not close. Return of pharmacologic response to an antihistamine after discontinuance of the drug takes from 3 to 14 days.
https://www.jacionline.org/article/0021-8707(51)90033-0/fulltext
I mean this is anecdote so take it as you will, but the rotating advice is straight from my own doc after we bitched about benadryl not working anymore.
Granted, this was a solid 20 or so years ago, so new findings and best practice are expected.
But, benadryl remains a dud for me, while I haven’t developed a tolerance to any of the others.
Glad it helps you get by! I hadn’t heard of the rotating antihistamines trick and was curious about the mechanism, so I asked Dr. DuckDuckGo. Could’ve always been some other tolerance mechanism, like faster breakdown of the drug, which rotating might help with. The paper does mention benadryl and a handful of other substances, but it’s also ancient by research standards, so I don’t know if that applies to all antihistamines or if some circumvent tolerance induction somehow.
Bonus tip tradeoff: you just lost any benefit you might have been gaining from the placebo effect. Sorry.
Only if I believe you, eh heh heh~~
the hatman is most definitely a thing. He’s the final boss of the shadow ppl stage
I got allergies late in life.
I thought “Benadryl — like ibuprofen, right? Two to just get started…”
Took two. Nose still dripping like a faucet. Took two more. Then went for a motorcycle ride.
An hour into the ride: “I should just lie down in the middle of the road and take a nap…”
It’s pretty clearly marked, “DO NOT DRIVE OR OPERATE HEAVY MACHINERY” but glad you didn’t kill yourself or someone else 👍
Maybe the motorcycle was light?
No it isn’t. It’s the seventh of eight bullet points, and it says “use caution when operating a vehicle.”
It also not safe to take 4 Ibuprofen. The max recommended dose is something like 600mg per 12 hours for an adult. I learned last week you need prescription for Ibuprofen in Germany.
No, you don’t. I just bought some no questions asked at a german pharmacy
The pharmacist told me you need prescription for the 600mg ones. Maybe last strong pills are without prescription.
It isn’t safe everything has risks that come with it but recommended daily maximums in the USA I was last aware of are 600mg every 6 hours or 800mg every 8 hours, aka 2,400mg / 24 hours. In the past doses approaching that often included taking famotidine (pepcid AC) in an effort to reduce the ulcer risk that comes from it. There are also possible long term heart implications as other risks. Also never mix NSAIDs, non steroidal anti inflammatory drugs (don’t take ibuprofen with naproxen, diclofenac, etc). 800mg of ibuprofen is very unlikely to kill you taken one time during an acute event assuming you aren’t allergic to it or have taken something else that interacts with it. 800mg of ibuprofen taken regularly is likely to shorten your lifespan.
edit so yeah discuss it with YOUR doctor not some rando on the internet but I wouldn’t be concerned about taking 800mg to be able to get to your doctor personally (assuming nothing else in your system)
i guess you need a prescription for higher dosage ibus, but 400mg ones are freely available.
The hat man always gets his due.
24 benadryl: ĭ̵̛̖̱͔̺̦͚̗̲̠͈͈͉͚̃̽̅́̍̐̏t̶̳̰̱̩̿́̑̅̌ ̷̨̻̹̙̦̔͐̈͗̒̕͜c̷̛̛̦̅̀͌́̌̎̒̕̚o̸̢̠̝̣͖͙̱͚̝̐͐͘͠m̶͕͈͗̆͗͌̕͝e̸̢̛̤̯͈͈̻͈͑̾̽̈́̆̂̏́̔s̵̞̮͍̼̙̫̈́̒̒͊̂̔̑̐̓̕͘̕͝͝ͅ
Do we think he saw the hat man at 8?
Does Chlorphenamine do the same thing?
Piriton for those in the land of brands
Worse IMNSHO. Marazine and DXM. too. Early antihistamines and anti-nausea OTC.
Yea, deleriants are generally not fun
I’ve always known Benzedrine as bennies.
