Compounds responsible for the aroma of cannabis and many other plants may offer a surprising new way to relieve chronic pain. Researchers found that several cannabis-derived terpenes significantly reduced pain in mouse models of fibromyalgia and post-surgical pain, with one terpene, geraniol, showing especially strong effects. Unlike THC, these compounds are not associated with psychoactive effects, making them a potentially attractive alternative for pain treatment.
Caffeine and nicotine are problematic for various reasons, but they are not significantly mind-altering. Because of that, chronic use of caffeine and nicotine is not problematic with regard to being able to perform most tasks.
Oh wait, you’re serious.