Compounds responsible for the aroma of cannabis and many other plants may offer a surprising new way to relieve chronic pain. Researchers found that several cannabis-derived terpenes significantly reduced pain in mouse models of fibromyalgia and post-surgical pain, with one terpene, geraniol, showing especially strong effects. Unlike THC, these compounds are not associated with psychoactive effects, making them a potentially attractive alternative for pain treatment.
    • givesomefucks@lemmy.worldEnglish
      1·
      4 hours ago

      It’s a nice way of saying:

      We gave mice _____ to see if we could cure them of ____!

      https://pmc.ncbi.nlm.nih.gov/articles/PMC8621025/

      Explains it more in depth:

      Understanding and treating human diseases requires thorough knowledge of disease-causing molecular and pathophysiological mechanisms. Despite the recent advances in induced pluripotent stem cell techniques, many of these aspects remain challenging to study, especially under physiological conditions in patient-derived material [1,2]. In order to be reliable and valuable, the disease model should recapitulate if not the entire human disease phenotype, then at least the key features of each specific disease under study [3]. For precision medicine, a good understanding of the genetic bases of variation in phenotypes and their interaction with the environment in health and disease are required [4,5]. Thus, animal models, and especially genetically modified (GM) mice, offer great potential to serve as precious preclinical models that facilitate basic understanding of disease pathomechanisms and provide clues for the development of treatment options and novel strategies to follow a treatment’s response.