I’ve spent more time than I care to admit reading Wikipedia entries on significant people from past centuries. Way too often their life story is full of disease and death. A dozen siblings. All of them suffer the same disease in childhood. Half of them don’t make it to adulthood. Mother dies during childbirth. Father struggles making money from their creative work, dies in a duel. Subject cared for by wealthy uncle. Is affected for the remainder of their life by the lingering effects of the childhood disease. Repeat for the next generation.