Research Highlights: In a Phase 1, first-in-human trial, a one-time infusion of an investigational CRISPR-Cas9 therapy targeting angiopoietin-like protein 3 (ANGPTL3) was safe and reduced LDL cholesterol by nearly 50% and reduced triglycerides by...
First-in-human just means it’s the first time that specific therapy is being tested on humans instead of animals (e.g. mice, dogs, monkeys), and the primary objective of the trial is to test that it’s safe for use in humans. It doesn’t refer to the concept of gene editing or lowering cholesterol.
But I think the Chinese scientist that experimented on babies did it few years before that even. looks like same year, 2018, and thought emporium published first by 8 months
Is this the first human trial, or just the first officially sanctioned one?
IIRC there was that one guy who experimented on himself and cured his lactose intolerance.
… found it: https://www.youtube.com/watch?v=J3FcbFqSoQY
Nearly 8 years ago.
I feel obligated to mention that he doesn’t modify his own genes, he infects himself with a modified bacteria that produces lactase.
First-in-human just means it’s the first time that specific therapy is being tested on humans instead of animals (e.g. mice, dogs, monkeys), and the primary objective of the trial is to test that it’s safe for use in humans. It doesn’t refer to the concept of gene editing or lowering cholesterol.
Thought emporium?
Yep thought emporium.
But I think the Chinese scientist that experimented on babies did it few years before that even.looks like same year, 2018, and thought emporium published first by 8 monthshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6724388/
That paper is a wild read