So while Adderall is an Amphetamine, more specifically it’s multiple amphetamine salts packed into one container, and in high doses can cause psychosis, the major difference is that Methamphetamine’s Methyl chain at the attachment point makes it heavily lipophilic causing it to dissolve into body fats, causing its tooth-decay side effect and also making it easier to pass through the blood-brain barrier.
It’s slightly more lipophilic, not heavily so. The main draw of meth from a pharmacodynamic perspective is that it slows enzymatic degradation (you’re high longer). On a mg for mg basis dextroamphetamine is actually stronger than meth.
Tooth decay is caused by dry mouth and poor hygiene. The added methyl group doesn’t affect this aspect.
I’m no expert on illicit substances, but teeth are a bone matrix FILLED with lipids, that’s theorized to be why certain bacteria target and eat away at the teeth in the first place while other common bacteria simply produce acids which demineralize teeth as a side effect, and the Methyl compounds will bond directly to the teeth creating a dental biofilm in this case accelerating decay, this property is used by some dental coatings in order to apply permanent ceramic fixtures to teeth with methyl methacrylate and the property is also the major cause of stains on teeth caused by smoking.
Adderall also causes dry mouth but is not associated with the same level or severity of tooth decay.
This would probably actually make for a great area of research on if different “types” of meth like methoxy, methyl, halogen, or sulfur have different severities on dental health and if there is not then it would immediately prove me wrong, but I personally could not find any such study.
So while Adderall is an Amphetamine, more specifically it’s multiple amphetamine salts packed into one container, and in high doses can cause psychosis, the major difference is that Methamphetamine’s Methyl chain at the attachment point makes it heavily lipophilic causing it to dissolve into body fats, causing its tooth-decay side effect and also making it easier to pass through the blood-brain barrier.
It’s slightly more lipophilic, not heavily so. The main draw of meth from a pharmacodynamic perspective is that it slows enzymatic degradation (you’re high longer). On a mg for mg basis dextroamphetamine is actually stronger than meth.
Tooth decay is caused by dry mouth and poor hygiene. The added methyl group doesn’t affect this aspect.
I’m no expert on illicit substances, but teeth are a bone matrix FILLED with lipids, that’s theorized to be why certain bacteria target and eat away at the teeth in the first place while other common bacteria simply produce acids which demineralize teeth as a side effect, and the Methyl compounds will bond directly to the teeth creating a dental biofilm in this case accelerating decay, this property is used by some dental coatings in order to apply permanent ceramic fixtures to teeth with methyl methacrylate and the property is also the major cause of stains on teeth caused by smoking.
Adderall also causes dry mouth but is not associated with the same level or severity of tooth decay.
This would probably actually make for a great area of research on if different “types” of meth like methoxy, methyl, halogen, or sulfur have different severities on dental health and if there is not then it would immediately prove me wrong, but I personally could not find any such study.